Baclofen is used for treating spasm of skeletal muscles that cause muscle clonus, rigidity, and pain due to multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (also called striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. GABA released by some nerves causes the activity of other nerves to decrease. It is believed that Baclofen, acting like GABA, blocks the activity of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.
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